β-半乳糖苷酶染色試劑盒(β-Galactosidase Staining Kit)是一種基于衰老時SA-β-Gal (senescence-associated β-galactosidase)活性水平上調(diào)而對衰老細(xì)胞或組織進(jìn)行染色檢測的試劑盒。在普通的光學(xué)顯微鏡下就可以觀測到細(xì)胞或組織的衰老情況。本試劑盒可以用于培養(yǎng)細(xì)胞的衰老檢測，也可以用于組織切片的衰老檢測。β-半乳糖苷酶染色試劑盒以X-Gal為底物，在衰老特異性的β-半乳糖苷酶催化下會生成深藍(lán)色產(chǎn)物，光學(xué)顯微鏡下很容易觀察到變成藍(lán)色的表達(dá)β-半乳糖苷酶的細(xì)胞或組織。本試劑盒僅染色衰老細(xì)胞，對衰老前的細(xì)胞(presenescent cells)、靜止期細(xì)胞(quiescent cells)、永生細(xì)胞(immortal cells)或腫瘤細(xì)胞等不會染色。對于組織切片或組織塊，可以檢測的樣品數(shù)量視樣品的大小而定，對于普通的切片也至少足夠檢測100個樣品，使用6孔板測定，足夠測定100個樣品。 

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標(biāo)題:Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

成員:Gao Yuchen, Chi Ying, Chen Yunfei, Wang Wentian, Li Huiyuan, Zheng Wenting, Zhu Ping, An Jinying, Duan Yanan, Sun Ting, Liu Xiaofan, Xue Feng, Liu Wei, Fu Rongfeng, Han Zhibo, Zhang Yingchi, Yang Renchi, Cheng Tao, Wei Jun, Zhang Lei, Zhang Xiaomin

論文因子:16.6 發(fā)表期刊:Nature Communications pmid:37474525

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標(biāo)題:A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration

成員:Yuan Li, Kuo Zhang, Xuezheng Ai, Qingshi Zhang, Lu Jiang, Jiang Long, Huange Xu, Chencheng Feng, Yaqing Zhang, Guoke Tang, Fanli Chong, Lei Wang, Bo Huang

論文因子:13.3 發(fā)表期刊:Small pmid:37423970

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標(biāo)題:Peficitinib ameliorates doxorubicin-induced cardiotoxicity by suppressing cellular senescence and enhances its antitumor activity

成員:Hui Hua, Qi Zhao, Jing Xia, Qian-long Dai, Shi-rui Bai, Xiao-bo Wang, Min Zhou

論文因子:5.6 發(fā)表期刊:INTERNATIONAL IMMUNOPHARMACOLOGY pmid:37451017

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標(biāo)題:Extracellular vesicles derived from HuMSCs alleviate daunorubicin-induced cardiac microvascular injury via miR-186-5p/PARP9/STAT1 signal pathway

成員:Shule Zhang, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju

論文因子:4.3 發(fā)表期刊:Regenerative Therapy pmid:38327716

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標(biāo)題:The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of High-grade Serous Ovarian Cancer Through Acetylation of p53

成員:Ye Cong, Cheng Yan, Qian Xiaohong, Zhong Bo, Ma Jinchun, Guo Hongling

論文因子:2.4 發(fā)表期刊:BIOCHEMICAL GENETICS pmid:38388849

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β-半乳糖苷酶染色試劑盒

β-半乳糖苷酶染色試劑盒